Journal article
Facile construction of polyoxometalate-polymer hybrid nanoparticles with pH/redox dual-responsiveness
Y Gao, F Yang, Y Wang, APR Johnston, RN Duffin, PC Andrews, C Ritchie, GK Such
Chemical Science | Published : 2024
DOI: 10.1039/d4sc03814b
Open access
Abstract
Responsive nanomaterials have emerged as promising candidates for advanced drug delivery systems (DDSs), offering the potential to precisely target disease sites and enhance treatment efficacy. To fulfil their potential, such materials need to be engineered to respond to specific variations in biological conditions. In this work, we present a series of pH/redox dual-responsive hybrid nanoparticles featuring an amphiphilic shell polymer and a pH-responsive core polymer. These nanoparticles incorporate a polyoxometalate (POM), specifically the cobalt(iii)-substituted borotungstate ([BIIIW11O39CoIII]6−), loaded through coordination chemistry between the encapsulated CoIII ions of the POM and py..
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Grants
Awarded by University of Melbourne
Funding Acknowledgements
C. R. would like to thank Monash University and the Australian Research Council for funding this research (FT180100610). G. S Would like to the thank the Australian Research Council for funding this research (DP240102642). Y. G. would like to acknowledge the support of the University of Melbourne through the Melbourne Research Scholarship and the Dr Albert Shimmins Fund. We would like to acknowledge the Bio21 Lan Holmes Imaging Centre for support with Cryo-EM.